Please contact Dr. Ryan LaLumiere if you have any questions.

2024

McGregor, M.S., Cosme, C.V., and LaLumiere, R.T. (2024). Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats. Neuropsychopharmacology. doi: 10.1038/s41386-024-01846-x. pdf

2023

McGregor, M.S., and LaLumiere, R.T. (2023). Still a “Hidden Island”? The rodent insular cortex in drug seeking, reward, and risk. Neuroscience and Biobehavioral Reviews. pdf

Glickman, B., and LaLumiere, RT. (2023). Theoretical considerations for optimizing the use of optogenetics with complex behavior. Current Protocols, 3, e836. doi: 10.1002/cpz1.836. pdf

Nett, K.E., Zimbelman, A.R., McGregor, M.S., Alizo Vera, V., Harris, M.R., and LaLumiere, R.T. (2023). Infralimbic projections to the nucleus accumbens shell and amygdala regulate the encoding of cocaine extinction learning. Journal of Neuroscience. doi: 10.1523/JNEUROSCI.2023-22.2022. pdf

Nett, K.E., and LaLumiere, R.T. (2023). Pair housing does not alter incubation of craving, extinction, and reinstatement after heroin self-administration in female and male rats. Behavioral Neuroscience. doi: 10.1037/bne0000544. pdf

2022

Gupta, S.C., Ghobbeh, A., Taugher-Hebl, R.J., Fan, R., Hardie, J.B., LaLumiere, R.T., and Wemmie, J.A. (2022). Carbonic anhydrase 4 disruption decreases synaptic and behavioral adaptations induced by cocaine withdrawal. Science Advances. doi: 10.1126/sciadv.abq5058. pdf

Müller Ewald, V.A., Kim, J., Farley, S.J., Freeman, J.H., and LaLumiere, R.T. (2022). Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction. Addiction Biology. doi: 10.1111/adb.13106. pdf

2021

Canto-de-Souza, L., Demetrovich, P.G., Plas, S., Souza, R.R., Epperson, J., Wahlstrom, K.L., Nunes-de-Souza, R.L., LaLumiere, R.T., Planeta, C.S., and McIntyre, C.K. (2021). Daily optogenetic stimulation of the left infralimbic cortex reverses extinction impairments in male rats exposed to single prolonged stress. Frontiers in Behavioral Neuroscience. doi: 10.3389/fnbeh.2021.780326. pdf

Meyer, H.C., Sangha, S., Radley, J.J., LaLumiere, R.T., and Baratta, M.V. (2021). Environmental certainty influences the neural systems regulating responses to threat and stress. Neuroscience & Biobehavioral Reviews. doi: 10.1016/j.neubiorev.2021.10.014. pdf

Nett, K.E., and LaLumiere, R.T. (2021). Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled? Neuroscience & Biobehavioral Reviews. doi: 10.1016/j.neubiorev.2021.10.002. pdf

Roesler, R., Parent, M.B., LaLumiere, R.T., and McIntyre, C.K. (2021). Amygdala-hippocampal interactions in synaptic plasticity and memory formation. Neurobiology of Learning & Memory. doi: 10.1016/j.nlm.2021.107490. pdf

Briggs, S.B., Ware, C.B., Sharma, K., Davis, S.C., LaLumiere, R.T., and Parent, M.B. (2021). Postmeal optogenetic inhibition of dorsal hippocampal principal neurons increases future intake in a time-dependent manner. Neurobiology of Learning & Memory. doi: 10.1016/j.nlm.2021.107478. pdf

Wahlstrom, K.L., Alvarez-Dieppa, A.C., McIntyre, C.K., and LaLumiere, R.T. (2021). The medial entorhinal cortex mediates basolateral amygdala effects on spatial memory and downstream activity-regulated cytoskeletal-associated protein expression. Neuropsychopharmacology. doi: 10.1038/s41386-020-00875-6. pdf

2020

Lingg, R.T., Johnson, S.B., Emmons, E.B., Anderson, R.M., Romig-Martin, S.A., Narayanan, N.S., McGaugh, J.L., LaLumiere, R.T., and Radley, J.J. (2020). Bed nuclei of the stria terminalis modulate memory consolidation via glucocorticoid-dependent and -independent circuits. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1915501117. pdf

2019

Muller Ewald, V.A. and LaLumiere, R.T. (2019). Response-contingent optogenetics to discover the mechanisms of nicotine-cue associations. Neuropsychopharmacology. doi:10.1038/s41386-019-0469-6. pdf

Hannapel, R., Ramesh, J., Ross, A., LaLumiere, R.T., Roseberry, A.G., and Parent, M.B. (2019). Postmeal optogenetic inhibition of dorsal or ventral hippocampal pyramidal neurons increases future intake. eNeuro. doi: 10.1423/ENEURO.0457-18. pdf

2018

Johnson, S., Emmons, E., Lingg, R., Anderson, R., Romig-Martin, S., LaLumiere, R.T., Narayanan, N., Viau, V., and Radley, J.J. (2018). Prefrontal-bed nucleus circuit modulation of a passive coping response. Journal of Neuroscience. doi: 10.1523/JNEUROSCI.1421-18.2018. pdf

Ghobbeh, A., Taugher, R., Alam, S., Fan,R., LaLumiere, R.T., and Wemmie, J.A. (2018). A novel role for acid-sensing ion channels (ASIC1A) in Pavlovian reward conditioning. Genes, Brain, and Behavior. doi: 10.1111/gbb.12531. pdf

Gutman, A.L., Cosme, C.V., Noterman, M.F., Worth, W.R., Wemmie, J.A., and LaLumiere, R.T. (2018). Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine-seeking behavior. Addiction Biology. doi: 10.1111/adb.12690. pdf

Muller Ewald, V.A., De Corte, B.J., Gupta, S.C., Lillis, K.V. Narayanan, N.S., Wemmie, J.A., and LaLumiere, R.T. (2018). Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins. Psychopharmacology. doi: 10.1007/s00213-018-4964-y. pdf

Wahlstrom, K.L., Huff, M.L., Emmons, E.B., Freeman, J.H., Narayanan, N.S., McIntyre, C.K., and LaLumiere, R.T. (2018). Basolateral amygdala inputs to the medial entorhinal cortex selectively modulate the consolidation of spatial and contextual learning. Journal of Neuroscience, 38: 2698-2712. pdf

Cosme, C.V., Gutman, A.L., Worth, W.R., and LaLumiere, R.T. (2018). D1, but not D2, receptor blockade within the infralimbic cortex and medial orbitofrontal cortex impairs the reinstatement of cocaine seeking in a region-specific manner. Addiction Biology, 23: 16-27. pdf

2017

Ewald, V.A., and LaLumiere, R.T. (2017). Neural systems mediating the inhibition of cocaine-associated memories. Pharmacology, Biochemistry, and Behavior, doi: 10.1016/j.pbb.2017.07.006. pdf

Gutman, A.L., Nett, K.E., Cosme, C.V., Worth, W.R., Gupta, S.C., Wemmie, J.A., and LaLumiere, R.T. (2017). Extinction of cocaine seeking requires a window of infralimbic pyramidal neuron activity after unreinforced lever presses. Journal of Neuroscience, 37: 6075-6086. pdf

LaLumiere, R.T., McGaugh, J.L., and McIntyre, C.K. (2017). Emotional modulation of learning and memory: Pharmacological implications. Pharmacological Reviews, 69: 236-255. pdf

Gutman, A.L., Ewald, V.A., Cosme, C.V., Worth, W.R., and LaLumiere, R.T. (2017). The infralimbic and prelimbic cortices contribute to the inhibitory control of cocaine-seeking behavior during a discriminative stimulus task in rats. Addiction Biology, 22: 1719-1730. pdf

2016

Johnson, S.B., Emmons, E.B., Anderson, R.M., Glanz, R.M., Romig-Martin, S.A., Narayanan, N.S., LaLumiere, R.T., and Radley, J.J. (2016). A basal forebrain site coordinates the modulation of endocrine and behavioral stress responses via divergent neural pathways. Journal of Neuroscience, 36: 8687-8699. pdf

Huff, M.L., Emmons, E.B., Narayanan, N.S., and LaLumiere, R.T. (2016). Basolateral amygdala projections to ventral hippocampus modulate the consolidation of footshock, but not contextual, learning in rats. Learning & Memory, 23: 51-60. pdf

2015

Radley, J.J., Anderson, R.M., Cosme, C.V., Glanz, R.M., Miller, M.C., Romig-Martin, S.A., and LaLumiere, R.T. (2015). The contingency of cocaine administration accounts for structural and functional medial prefrontal deficits and increased adrenocortical activation. Journal of Neuroscience, 35: 11897-11910. pdf

Cosme, C.V., Gutman, A.L., and LaLumiere, R.T. (2015) The dorsal agranular insular cortex regulates the cued reinstatement of cocaine-seeking, but not food-seeking, behavior in rats. Neuropsychopharmacology. (Epub ahead of print). pdf

Huff, M.L., and LaLumiere, R.T. (2015). The rostromedial tegmental nucleus modulates behavioral inhibition following cocaine self-administration in rats. Neuropsychopharmacology, 40: 861-873. pdf

2014

Kreple, C.J., Lu, Y., Taugher, R.J., Schwager-Gutman, A.L., Du, J., Stump, M., Wang, Y., Ghobbeh, A., Fan, R., Cosme, C.V., Sowers, L.P., Welsh, M.J., Radley, J.J., LaLumiere, R.T, and Wemmie, J.A. (2014). Acid-sensing ion channels in the nucleus accumbens contribute to synaptic transmission and inhibit cocaine-associated plasticity. Nature Neuroscience, 17: 1083-1091. pdf

LaLumiere, R.T. (2014). Optogenetic dissection of amygdala functioning. Frontiers in Behavioral Neuroscience, 8. pdf

Mahler, S.V., Hensley-Simon, M., Tahsili-Fahadan, P., LaLumiere, R.T., Thomas, C., Fallon, R.V., Kalivas, P.W., and Aston-Jones, G. (2014). Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addiction Biology, 19, 49-60. pdf

2013

Huff, M.L., Miller, R.L., Deisseroth, K., Moorman, D.E., and LaLumiere, R.T. (2013). Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory avoidance memory in rats. Proceedings of the National Academy of Sciences, 110: 3597-3602. pdf

Stefanik, M.T., Moussawi, K., Kupchik, Y.M., Smith, K.C., Miller, R.L., Huff, M.L., Deisseroth, K., Kalivas, P.W., and LaLumiere, R.T. (2013). Optogenetic inhibition of cocaine seeking in rats. Addiction Biology, 18: 50-53. pdf

2012

Trantham-Davidson, H., LaLumiere, R., Reissner, K., Kalivas, P., and Knackstedt, L. (2012). Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport and export following cocaine self-administration and extinction training. Journal of Neuroscience, 32, 12406-12410. pdf

LaLumiere, R.T., Smith, K.C., and Kalivas, P.W. (2012). Neural circuit competition in cocaine-seeking: Roles of the infralimbic cortex and nucleus accumbens shell. European Journal of Neuroscience, 35, 614-622. pdf

2011

LaLumiere, R.T. (2011). A new technique for controlling the brain: Optogenetics and its potential for use in research and the clinic. Brain Stimulation, 4, 1-6. pdf

2010

Knackstedt, L.A., Moussawi, K., LaLumiere, R., Schwendt, M., Klugmann, M., & Kalivas, P.W. (2010). Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine-seeking. Journal of Neuroscience, 30, 7984-7992. pdf

LaLumiere, R.T. and Kalivas, P.W. (2010). Drug Priming. In Koob, G, Le Moal, M, and Thompson, R. (eds). Encyclopedia of Behavioral Neuroscience. Academic Press, p. 431-436.

LaLumiere, R.T., Niehoff, K.E., and Kalivas, P.W. (2010). The infralimbic cortex regulates the consolidation of extinction training after cocaine self-administration. Learning and Memory, 17, 168-175. pdf

2009

Berglind, W., Whitfield, T., LaLumiere, R. T., Kalivas, P.W., and McGinty, J.F. (2009). A Single Intra-PFC Infusion of BDNF Prevents Cocaine-Induced Alterations in Extracellular Glutamate Within the Nucleus Accumbens. Journal of Neuroscience, 29, 3715-3719. pdf

2008

LaLumiere, R.T., and Kalivas, P.W. (2008). Cocaine Addiction: Mechanisms of Action. Psychiatric Annals, 38, 252-258. pdf

LaLumiere, R.T., and Kalivas, P.W. (2008). Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin-Seeking.  Journal of Neuroscience, 28, 3170-7. pdf

2005

LaLumiere, R.T., and McGaugh, J.L. (2005). Memory enhancement induced by intra-basolateral amygdala infusions of b-adrenergic or muscarinic agonists require activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala.  Learning & Memory, 12, 527-532. pdf

2004

LaLumiere, R.T., Nguyen, L.T., and McGaugh, J.L. (2004). Posttraining intra-basolateral amygdala infusions of dopamine modulate consolidation of inhibitory avoidance memory: Involvement of noradrenergic and cholinergic systems. European Journal of Neuroscience, 20, 2804-2810. pdf

LaLumiere, R.T., Pizano, E., and McGaugh, J.L. (2004). Intra-basolateral amygdala infusions of AP-5 impair or enhance retention of inhibitory avoidance depending on training conditions.  Neurobiology of Learning and Memory, 81, 60-66. pdf

2003

Miranda, M.I., LaLumiere, R.T., Buen, T.V., Bermudez-Rattoni, F., and McGaugh, J.L. (2003).  Blockade of noradrenergic receptors in the basolateral amygdala impairs taste memory.  European Journal of Neuroscience, 18, 2605-2610. pdf

LaLumiere, R.T., Buen, T.-V., and McGaugh, J.L. (2003).  Posttraining intra-basolateral amygdala infusions of norepinephrine enhance consolidation of memory for contextual fear conditioning. Journal of Neuroscience, 23, 6754-6758. pdf